Access to folder on Server

i have rather weird problem stuck with.  have created user groups, i.e, accounting, sales, administration, etc. , have put users departement groups.  groups have set permissions access folder on server.  there change , 1 group, has 2 users, needs have access folder well.  easy enough?  have changed permission folder , user group , weird thing 1 user in group can access folder , other user in group gets access denied.  have tried change everything, inherit permissions, remove inherit, apply point child objects, etc. still same.  has idea why happens?  stuck problem 3 days , nothing in sight , run out of ideas.  thank in advance.

how user trying access folder?

example, user accessing unc path (\\server\share) goes directly files?  browsing there way file locations double clicking series of folders?  going directly files accessing either \\server\share\dir1\dir2\dir3 or z:\dir1\dir2\dir3?  user getting denied using aforementioned methods? 

is users computer joined domain? 

is uer logged in domain?

how user accesses files important forming answer.

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